A Population Health Approach to Improving Opioid Prescribing How One Organization Leveraged Analytics to Reduce Hospital Admissions by 36.8% The epidemic of prescription opioid misuse and overdose in the United States is now widely recognized by physicians and other prescribers, government officials and health care systems. Opioid overdose is now responsible for over two thirds of emergency department visits in the U.S. (Yokell et al., 2014). In 2010, a total of 16,651 deaths resulted from overdoses with prescription opioids (Dart et al., 2015). Primary care physicians recognize these alarming trends: A recent national survey showed that 90% “reported prescription drug abuse to be a ‘big’ or ‘moderate’ problem in their communities, and more than four-fifths (85%) reported that opioids are overused in clinical practice” (Hwang et al., 2014). The National Association of State Medicaid Directors, in conjunction with Mercer Government Human Services Consulting, recently issued a report citing prescription drug abuse as a serious public health concern, urging states to address prescription drug abuse through a coordinated, multifaceted approach (Mercer, 2014) and the CDC has issued grants to 16 states to address this ever growing epidemic. The Solution Relias Analytics supports PDMP activation and enhancements by offering clinically-driven patient-specific reporting and prescriber peer comparative data to improve community standards of care. The opioid specific solution (OPI) is available to the entire care team— physicians, clinicians, pharmacists, and other care givers—all who have a role in the improvement of opioid use and misuse. The results of a recent study with Relias partner MO HealthNet—a 36.8% reduction in hospital admissions, 13–37% drop in opioid pharmacies used, and a 15–19% decrease in average adult monthly (in morphine equivalents) opioids dispensed—point to the results that can be achieved. “Relias Analytics supports PDMP activation and enhancements by offering clinically driven patient-specific reporting and prescriber peer comparative data to improve community standards of care.” The Relias Analytics solution provided actionable insights that allowed professionals in a variety of roles to improve. Physicians were helped in reducing variability and misuse in the application and administration of pain medication. Care coordinators were better able to identify patients at risk for misuse or in need of substance abuse screening and/or intervention. Quality improvement staff were supported with tools to measure and track performance. Clinical and medical directors were able to target opportunities for program and clinical development. In addition, payers were able to assess opportunities for financial savings.